Title:
33ALKYLQITHANTINE COMPOUMD
Document Type and Number:
Japanese Patent JPS5557589
Kind Code:
A
Abstract:
3-Alkylxanthines characterized by the formula
wherein R<1> is n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobuty, cyclopentyl of cyclohexylmethyl, and R<2> is hydrogen or methyl, provided that R<2> is methyl when R<1> is n-propyl, n-butyl or isobutyl, or a physiologically acceptable salt thereof, for example the compound 3-cyclopetnyl-3, 7-dihydro-1H-purine-2, 6-dione, have activity against chronic obstructive airway disease or cardiac disease. These compounds are produced by several methods, exemplified by the following one: reacting a compound of the formula
with a compound of the formula
R<2>-X
wherein R<1> and R<2> have the definition given above and X is -COOH, -CONH2 or -OC-O-CO-R2 and, if necessary, submitting the obtained product to dehydration. The starting compounds wherein R<1> is n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, cyclopentyl or cylohexylmethyl are not previously described in teh literature They are prepared by reacting a compound of the formula R<1>NHCONH2 with cyanoacetic acid, cyclising the produced 1-cyanoycetyl-3-R<1>urea with alkali, nitrosing the so produced 1-R<1>-6-aminouracil with HNO2 and reducing the so produced 1-R<1>-5-nitroso-6-aminouracil with H2//PtO2.
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Inventors:
PERU GUNNAA CHIERIN
KAARU GERAN AUGUSUTO PERUSON
KAARU GERAN AUGUSUTO PERUSON
Application Number:
JP13584579A
Publication Date:
April 28, 1980
Filing Date:
October 19, 1979
Export Citation:
Assignee:
DRACO AB
International Classes:
A61K31/52; A61K31/522; C07D473/04; A61P9/00; A61P9/04; A61P11/08; C07D239/545; C07D473/06; C07D239/54; (IPC1-7): A61K31/52; C07D473/06
Domestic Patent References:
| JPS4716111B1 | ||||
| JPS52133295U | 1977-10-11 | |||
| JPS5125009U | 1976-02-24 | |||
| JPS5345102U | 1978-04-18 |