Title:
HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3), AND USES THEREOF
Document Type and Number:
Japanese Patent JP2019030307
Kind Code:
A
Abstract:
To provide isolated monoclonal antibodies that specifically bind to LAG-3 with high affinity, particularly human monoclonal antibodies.SOLUTION: Antibodies bind human LAG-3 are provided. The antibodies bind both human and monkey LAG-3 but do not bind mouse LAG-3. The invention provides anti-LAG-3 antibodies that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. This disclosure also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody. Combination therapy, in which an anti-LAG-3 antibody is co-administered with at least one additional immunostimulatory antibody, is also provided.SELECTED DRAWING: None
Inventors:
KENT B THUDIUM
ALAN J KORMAN
HEIDI LEBLANC
MARK YAMANAKA
MARK SELBY
KYRA D ZENS
ALAN J KORMAN
HEIDI LEBLANC
MARK YAMANAKA
MARK SELBY
KYRA D ZENS
Application Number:
JP2018177601A
Publication Date:
February 28, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
E R SQUIBB & SONS LLC
International Classes:
C12N15/63; A61K39/395; A61K47/68; A61K51/10; A61P31/12; A61P35/00; A61P37/04; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12P21/08
Domestic Patent References:
| JP2000502324A | 2000-02-29 | |||
| JP5647981B2 | 2015-01-07 | |||
| JPH09508023A | 1997-08-19 |
Foreign References:
| WO2006121168A1 | 2006-11-16 |
Other References:
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MACON-LEMAITRE, L. AND TRIEBEL, F., IMMUNOLOGY, vol. 115, JPN6015048127, 2005, pages 170 - 178, ISSN: 0004119987
WORKMAN, C.J. ET AL., EUR. J. IMMUNOL., vol. 32, JPN6015048128, 2002, pages 2255 - 2263, ISSN: 0004119988
HUARD, B. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, JPN6015048122, 1997, pages 5744 - 5749, ISSN: 0004119981
DYRBERG, T. AND OLDSTONE, M.B.A., J. EXP. MED., vol. 164, JPN6020030982, 1986, pages 1344 - 1349, ISSN: 0004330314
TANAKA, T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, JPN6020030984, 1985, pages 3400 - 3404, ISSN: 0004330315
SHAPIRA, M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, JPN6020030986, 1984, pages 2461 - 2465, ISSN: 0004330316
KUROKI, M. ET AL., ANTICANCER RESEARCH, vol. 25, JPN6019036796, 2005, pages 3733 - 3740, ISSN: 0004119982
GROSSO, J.F. ET AL., J. CLIN. INVEST., vol. 117, no. 11, JPN6015048129, 2007, pages 3383 - 3392, ISSN: 0004119989
LONBERG, N. ET AL., NATURE, vol. 368, JPN6015048130, 1994, pages 856 - 859, ISSN: 0004119990
BAIXERAS, E. ET AL., J. EXP. MED., vol. 176, JPN6015048119, 1992, pages 327 - 337, ISSN: 0004119983
FISHWILD, D.M. ET AL., NATURE BIOTECHNOL., vol. 14, JPN6015048120, 1996, pages 845 - 851, ISSN: 0004119984
PARDOLL, D. ET AL., CANCER IMMUNOTHERAPY, JPN6015048121, 2007, pages 257 - 275, ISSN: 0004119985
HUARD, B. ET AL., IMMUNOGENETICS, vol. 39, JPN6015048125, 1994, pages 213 - 217, ISSN: 0004119986
MACON-LEMAITRE, L. AND TRIEBEL, F., IMMUNOLOGY, vol. 115, JPN6015048127, 2005, pages 170 - 178, ISSN: 0004119987
WORKMAN, C.J. ET AL., EUR. J. IMMUNOL., vol. 32, JPN6015048128, 2002, pages 2255 - 2263, ISSN: 0004119988
Attorney, Agent or Firm:
Norihito Yamao
Kenji Tomita
Fumio Inai
Manami Sasakura
Kenji Tomita
Fumio Inai
Manami Sasakura