Title:
4-ARYL-1-PHENYLALKYL-1, 2, 3, 6-TETRAHYDROPYRIDINE HAVING NEUROTROPHIC ACTIVITY AND NERVE-PROTECTINC ACTIVITY
Document Type and Number:
Japanese Patent JP3302351
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new process for the production of a biphenyl derivative.
SOLUTION: The objective compound expressed by formula (t) [the benzene ring may be substituted; X' is phenyl which may be mono-substituted with a halogen, CF3, a 1-4C alkyl, a 1-4C alkoxy, cyano, amino, a 1-4C alkylamino, a 1-4C acylamino, carboxyl, a 1-4C alkoxycarbonyl, aminocarbonyl, a 1-4C alkylaminocarbonyl, a 1-4C aminoalkyl, a 1-4C hydroxyalkyl or a 1-4C halogenoalkyl] is produced by reacting a compound of formula (w) [the benzene ring may be substituted; L, is an eliminable group] with a benzene boric acid of formula X'-B(OH)2 [X' is same as the one defined above] in an aqueous medium in the presence of a palladium salt, a strong base and a phase-transfer agent.
Inventors:
Domenico Badone
Marco Baroni
Losanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Alessandra Yermini
Marco Baroni
Losanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Alessandra Yermini
Application Number:
JP2000231069A
Publication Date:
July 15, 2002
Filing Date:
June 26, 1996
Export Citation:
Assignee:
SANOFI-SYNTHELABO
International Classes:
A61K31/4418; A61K31/4427; A61K31/444; A61K31/445; A61K31/451; A61K31/4523; A61P25/00; A61P25/28; A61P35/00; C07B37/04; C07B61/00; C07C1/32; C07C15/14; C07C29/34; C07C33/46; C07C41/48; C07C43/174; C07C51/353; C07C57/58; C07C67/343; C07C69/65; C07D211/52; C07D211/70; C07D401/04; A61K31/00; (IPC1-7): C07B37/04; C07C1/32; C07C29/34; C07C33/46; C07C67/343; C07C69/65
Domestic Patent References:
| JP892132A | ||||
| JP840948A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)