ACONITINE-CONTAINING SYNTHESIS INHIBITOR OF PROTEIN BELONGING TO HSP27 FAMILY

Title:

ACONITINE-CONTAINING SYNTHESIS INHIBITOR OF PROTEIN BELONGING TO HSP27 FAMILY

Document Type and Number:

Japanese Patent JPH1036261

Kind Code:

A

Abstract:

To obtain the subject medicine capable of treating a cancer and a multiple sclerosis, containing an aconitine as an active ingredient.

This medicine comprises aconitine or its stereoisomer as an active ingredient. Aconitine as a component of a crude medicine Aconiti tuber shows specifically suppressing action on synthesis of heat shock protein (called HSP27 family) having 16 to 40 kilodalton molecular weight in a cell of tissue exhibiting the state of a disease. Consequently, an autoimmune disease such a cancer related to the deterioration of the protein belong to SHP27 family or reduction in effect of thermotherapy can be treated by administration of aconitine. A daily dose is 1-100mg calculated as aconitine per adult and administered once to four times orally or parenterally. The medicine can be administered as a medicine or a functional food or a health food in the form of food and beverage. The medicine can suppress medicine resistance and enhance the effect of chemotherapy.

Inventors:

SHOBU YOICHI
TSUZUKI TOMOKO
SHIRAGAMI TOSHIMI
MORINO MASAYOSHI
YOSHIKUMI CHIKAO

Application Number:

JP21431796A

Publication Date:

February 10, 1998

Filing Date:

July 25, 1996

Export Citation:

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Assignee:

KUREHA CHEMICAL IND CO LTD

International Classes:

C07D221/22; A61K31/435; A61K36/00; A61K36/71; A61P25/00; A61P35/00; A61P37/00; A61P43/00; (IPC1-7): A61K31/435; A61K31/435; A61K35/78

Attorney, Agent or Firm:

Kenichi Morita

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