Title:
ACTIVATED ZINC, ITS USE, METHOD FOR PREPARING THE SAME AND METHOD FOR PREPARING ETHYL 3-HYDROXY-3-(2- PHENYLETHYL)HEXANOATE USING THE SAME
Document Type and Number:
Japanese Patent JP2003112045
Kind Code:
A
Abstract:
To provide a method for easily preparing ethyl 3-hydroxy-3-(2- phenylethyl)hexanoate in high yield useful as a raw material of pharmaceuticals and to provide an activated zinc useful for an organic synthesis reaction and a method for easily and safely preparing the activated zinc.
The activated zinc has been activated with chlorotrimethylsilane and a copper compound in an aprotic organic solvent. In the method for preparing ethyl 3-hydroxy-3-(2-phenylethyl)hexanoate, the activated zinc, ethyl bromoacetate and 1-phenyl-3-hexanone are brought into a Reformatskij reaction.
Inventors:
TANAKA MASAHIDE
MATSUI KOZO
ITAYA NOBUSHIGE
MATSUI KOZO
ITAYA NOBUSHIGE
Application Number:
JP2001308011A
Publication Date:
April 15, 2003
Filing Date:
October 03, 2001
Export Citation:
Assignee:
SUMIKA FINE CHEMICALS CO LTD
International Classes:
B01J23/06; C07B61/00; C07C29/40; C07C33/20; C07C45/30; C07C49/213; C07C67/31; C07C67/333; C07C69/732; (IPC1-7): B01J23/06; C07C29/40; C07C33/20; C07C45/30; C07C49/213; C07C67/31; C07C67/333; C07C69/732
Attorney, Agent or Firm:
Takashima Hajime