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Title:
Active protease tolerance antibody Fc mutant
Document Type and Number:
Japanese Patent JP6012624
Kind Code:
B2
Abstract:
The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.

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Inventors:
Brezski, Landale
Robert, Jordan
Stroll, William
Application Number:
JP2013546229A
Publication Date:
October 25, 2016
Filing Date:
December 15, 2011
Export Citation:
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Assignee:
Janssen Biotech, Inc.
International Classes:
A61K39/395; C07K16/32; A61P31/04; A61P35/00; A61P43/00; C07K16/46; C07K19/00; C12N15/09
Domestic Patent References:
JP2010536037A
Other References:
Proc Natl Acad Sci USA. 2009, vol.106, no.42, p.17864-17869
Eur J Immunol, 1999, vol.29, p.2613-2624
Curr Opin Biotechnol, 2009, vol.20, no.6, p.685-691
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Koichi Iwata
Yasuhito Suzuki



 
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