Title:
ADIPONECTIN PRODUCTION PROMOTOR
Document Type and Number:
Japanese Patent JP2006273839
Kind Code:
A
Abstract:
To provide a medicament containing a compound having strong activity for promoting production of adiponectin as an active ingredient.
The medicament contains a compound represented by general formula (1) [wherein, R1 and R2 are each a hydrogen atom, a hydroxy group or an alkoxy group; X is a 1-6C alkylene or the like; Y is an amide group, an ester group or the like; Z is a 1-20C alkylene or the like; and Q is a hydrogen atom, an aromatic hydrocarbon group or the like] as the active ingredient.
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Inventors:
YAMAZAKI YUKINAE
KONO YASUHIRO
KAMIBAYASHI MASAMI
KONO YASUHIRO
KAMIBAYASHI MASAMI
Application Number:
JP2005218519A
Publication Date:
October 12, 2006
Filing Date:
July 28, 2005
Export Citation:
Assignee:
NAT INST OF ADV IND & TECHNOL
International Classes:
A61K31/165; A61K31/166; A61K31/216; A61K31/235; A61K31/522; A61P3/06; A61P3/10; A61P43/00; C07C69/007; C07C69/92; C07C235/46
Other References:
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JPN6010047332, Ｈｏｓｓｅｉｎｉ Ｍ ｅｔ ａｌ．, "Ｕｓｉｎｇ ａｒｔｉｆｉｃｉａｌ ｎｅｕｒａｌ ｎｅｔｗｏｒｋｓ ｔｏ ｃｌａｓｓｉｆｙ ｔｈｅ ａｃｔｉｖｉｔｙ ｏｆ ｃａｐｓａｉｃｉｎ ａｎｄ ｉｔｓ ａｎａｌｏｇｕｅｓ．", Ｊ Ｃｈｅｍ Ｉｎｆ Ｃｏｍｐｕｔ Ｓｃｉ．, 199712, ３７巻６号, ｐｐ．１１２９−１１３７
JPN6010047333, Ｗａｌｐｏｌｅ ＣＳ ｅｔ ａｌ．, "Ａｎａｌｏｇｕｅｓ ｏｆ ｃａｐｓａｉｃｉｎ ｗｉｔｈ ａｇｏｎｉｓｔ ａｃｔｉｖｉｔｙ ａｓ ｎｏｖｅｌ ａｎａｌｇｅｓｉｃ ａｇｅｎｔｓ； ｓｔｒｕｃｔｕｒｅ−ａｃｔｉｖｉｔｙ ｓｔｕｄｉｅｓ．", Ｊ Ｍｅｄ Ｃｈｅｍ, 19930806, ３６巻１６号, ｐｐ．２３７３−２３８０
JPN6010047334, Ｗａｌｐｏｌｅ ＣＳ ｅｔ ａｌ．, "Ａｎａｌｏｇｕｅｓ ｏｆ ｃａｐｓａｉｃｉｎ ｗｉｔｈ ａｇｏｎｉｓｔ ａｃｔｉｖｉｔｙ ａｓ ｎｏｖｅｌ ａｎａｌｇｅｓｉｃ ａｇｅｎｔｓ； ｓｔｒｕｃｔｕｒｅ−ａｃｔｉｖｉｔｙ ｓｔｕｄｉｅｓ．", Ｊ Ｍｅｄ Ｃｈｅｍ．, 19930806, ３６巻１６号, ｐｐ．２３８１−２３８９
JPN6010047335, Ｇｕｉｌｌｏｔ Ｅ ｅｔ ａｌ．, "Ｉｎｖｏｌｖｅｍｅｎｔ ｏｆ ｃａｐｓａｉｃｉｎ−ｓｅｎｓｉｔｉｖｅ ｎｅｒｖｅｓ ｉｎ ｔｈｅ ｒｅｇｕｌａｔｉｏｎ ｏｆ ｇｌｕｃｏｓｅ ｔｏｌｅｒａｎｃｅ ｉｎ ｄｉａｂｅｔｉｃ ｒａｔｓ．", Ｌｉｆｅ Ｓｃｉ．, 1996, ５９巻１２号, ｐｐ．：９６９−９７７
JPN6010047332, Ｈｏｓｓｅｉｎｉ Ｍ ｅｔ ａｌ．, "Ｕｓｉｎｇ ａｒｔｉｆｉｃｉａｌ ｎｅｕｒａｌ ｎｅｔｗｏｒｋｓ ｔｏ ｃｌａｓｓｉｆｙ ｔｈｅ ａｃｔｉｖｉｔｙ ｏｆ ｃａｐｓａｉｃｉｎ ａｎｄ ｉｔｓ ａｎａｌｏｇｕｅｓ．", Ｊ Ｃｈｅｍ Ｉｎｆ Ｃｏｍｐｕｔ Ｓｃｉ．, 199712, ３７巻６号, ｐｐ．１１２９−１１３７
JPN6010047333, Ｗａｌｐｏｌｅ ＣＳ ｅｔ ａｌ．, "Ａｎａｌｏｇｕｅｓ ｏｆ ｃａｐｓａｉｃｉｎ ｗｉｔｈ ａｇｏｎｉｓｔ ａｃｔｉｖｉｔｙ ａｓ ｎｏｖｅｌ ａｎａｌｇｅｓｉｃ ａｇｅｎｔｓ； ｓｔｒｕｃｔｕｒｅ−ａｃｔｉｖｉｔｙ ｓｔｕｄｉｅｓ．", Ｊ Ｍｅｄ Ｃｈｅｍ, 19930806, ３６巻１６号, ｐｐ．２３７３−２３８０
JPN6010047334, Ｗａｌｐｏｌｅ ＣＳ ｅｔ ａｌ．, "Ａｎａｌｏｇｕｅｓ ｏｆ ｃａｐｓａｉｃｉｎ ｗｉｔｈ ａｇｏｎｉｓｔ ａｃｔｉｖｉｔｙ ａｓ ｎｏｖｅｌ ａｎａｌｇｅｓｉｃ ａｇｅｎｔｓ； ｓｔｒｕｃｔｕｒｅ−ａｃｔｉｖｉｔｙ ｓｔｕｄｉｅｓ．", Ｊ Ｍｅｄ Ｃｈｅｍ．, 19930806, ３６巻１６号, ｐｐ．２３８１−２３８９