Title:
難水溶性物質の高度なアクティブリポソームローディング
Document Type and Number:
Japanese Patent JP2014506922
Kind Code:
A
Abstract:
The present invention relates to the field of encapsulation of substances with low aqueous solubility in liposomes, especially via active loading. The present inventors have surprisingly found that efficient active loading of liposomes with high liposome loading can be achieved by first solubilizing a functional compound, which is itself hardly soluble in water using a solubility enhancer. This significantly increases the functional-substance-to-lipid mass ratio to levels above those attained by conventional active or passive loading techniques and enlarges the range of functional compounds, including drugs, amenable to encapsulation in liposomes. One aspect of the invention provides the active loading process. Liposomal compositions with high drug-load are provided by the present invention as well.
Inventors:
Guy Yard, Peter Jap
Apeldoorn, Chantal Catalina Maria
Lip, jacob
Apeldoorn, Chantal Catalina Maria
Lip, jacob
Application Number:
JP2013556568A
Publication Date:
March 20, 2014
Filing Date:
March 01, 2012
Export Citation:
Assignee:
Tio-Bee Bee Holding Besloten Fennaught Shap
International Classes:
A61K9/127; A61K31/4545; A61K47/12; A61K47/14; A61K47/16; A61K47/20; A61K47/22; A61K47/24; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/40
Domestic Patent References:
| JP2006280389A | 2006-10-19 | |||
| JP2007522085A | 2007-08-09 | |||
| JP2002527466A | 2002-08-27 | |||
| JP2007500239A | 2007-01-11 | |||
| JP2008106001A | 2008-05-08 | |||
| JP2006513189A | 2006-04-20 | |||
| JP2001510451A | 2001-07-31 | |||
| JPH02196713A | 1990-08-03 |
Foreign References:
| WO2010113983A1 | 2010-10-07 | |||
| US20080107722A1 | 2008-05-08 |
Attorney, Agent or Firm:
Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda
Kazuhiro Yamaguchi
Masakazu Noda