Title:
糖尿病随伴性および/または動脈性難治創傷の治療および/または予防のための、そして薬理学的に活性な物質を同定するための、アルファ1-アンチキモトリプシンポリペプチド類またはそれらをコード化している核酸の使用、または、ACTポリペプチドまたはそれをコード化している核酸を、発現している細胞の使用。
Document Type and Number:
Japanese Patent JP4384855
Kind Code:
B2
Abstract:
The invention relates to the use of alpha 1-antichymotrypsin (ACT) polypeptides according to SEQ ID No. 1 to SEQ ID No. 4, or a functional variant thereof and/or nucleic acids encoding them, or an antibody or a fragment thereof directed against the polypeptide, or of a cell which is expressing the polypeptide or a nucleic acid encoding it, for diagnosis, treatment and/or prevention of diabetes-associated and/or arterial wounds, which heal poorly and for identifying pharmacologically active substances which exert an influence on the expression or function, particularly the activity of ACT.
Inventors:
Halle, Jorn-Peter
Goppert, Andreas
Hoff, Peter
Goppert, Andreas
Hoff, Peter
Application Number:
JP2002585477A
Publication Date:
December 16, 2009
Filing Date:
April 30, 2002
Export Citation:
Assignee:
Switch Biotech Akchen Gesell Shaft
International Classes:
C12Q1/68; A61K35/36; G01N33/50; A61K35/76; A61K38/00; A61K38/55; A61K39/395; A61K45/00; A61K48/00; A61P17/02; A61P43/00; C07K14/81; C07K16/38; C07K19/00; C12N15/09; C12Q1/02; G01N33/15; G01N33/573
Domestic Patent References:
| JP9512422A | ||||
| JP3181422A | ||||
| JP6500560A |
Foreign References:
| WO1992006706A1 | ||||
| US5422244 |
Other References:
Inglis, J.D. et al.,Gene,1991年,Vol.106(2),p.213-20
T. Chandra et al.,Biochemistry,1983年,Vol.22, No.22,p.5055-5061
Schmidtchen, A.,Acta. Derm. Venereol.,1999年,Vol.79(4),p.291-5
Rao, C. N., et al.,Clinical Research,1994年,Vol.42(3),p.428A
T. Chandra et al.,Biochemistry,1983年,Vol.22, No.22,p.5055-5061
Schmidtchen, A.,Acta. Derm. Venereol.,1999年,Vol.79(4),p.291-5
Rao, C. N., et al.,Clinical Research,1994年,Vol.42(3),p.428A
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami