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Title:
ALPHA-GLUCOSIDASE INHIBITOR
Document Type and Number:
Japanese Patent JPH07188205
Kind Code:
A
Abstract:

PURPOSE: To obtain an α-glucosidase inhibitor containing a specific enopyranose derivative or its salt as an active ingredient, useful as a reagent for studying glucoprotein sugar chain processing and a medicine for treating viral diseases such as metastasis and AIDS, diabetes mellitus, etc.

CONSTITUTION: This α-glucosidase inhibitor contains an enopyranose derivative of formula I (R1 and R2 each is H or an alkyl; R3 is H or an acyl; R4 is OH, an acyloxy or R3 and R4 together form a single bond; X is H or an acyl) or its salt as an active ingredient. As the compound of formula I as the active ingredient, especially, an enopyranose derivative expressed by formula II or formula III or its salt is preferably used. In the compound of formula I, a combination in which R1 is H or an alkyl and R2 is an alkyl and X us H or an acyl is preferable. Further, the compound of formula I in which X is furan carbonyl or thiophene carbonyl is preferable. This α-glucosidase inhibitor is useful as a medicine for treating hyperlipemia, inflammatory diseases, autoimmune diseases, rejection in organ transplantation, allergic diseases, etc., especially as metastasis inhibitor.


Inventors:
KATO FUMINORI
TSUKAMOTO MASAMITSU
Application Number:
JP35211893A
Publication Date:
July 25, 1995
Filing Date:
December 27, 1993
Export Citation:
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Assignee:
ISHIHARA SANGYO KAISHA
International Classes:
C12N9/99; A61K31/35; A61K31/351; A61P3/06; A61P3/08; A61P3/10; A61P29/00; A61P31/12; A61P31/18; A61P37/06; A61P37/08; A61P43/00; C07D309/30; C07D493/08; C07D493/20; (IPC1-7): C07D309/30; A61K31/35; C07D493/08; C12N9/99