Title:
カリウムチャネルの機能を調節するアミン誘導体、その調製方法及びその使用
Document Type and Number:
Japanese Patent JP4279685
Kind Code:
B2
Abstract:
The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.
Inventors:
One high
Yan Rifan
Ron Chaolyang
Yun Liu Hong
Cuy wen yu
One Lin
Fen Hwa Sung
Gaoxiu
Rushin Kyan
Zaurushen
Yang Yuan
Hephamei
Liu Way
Refrin
Fugan
Liu Lijun
Tan Shinchun
Yan Rifan
Ron Chaolyang
Yun Liu Hong
Cuy wen yu
One Lin
Fen Hwa Sung
Gaoxiu
Rushin Kyan
Zaurushen
Yang Yuan
Hephamei
Liu Way
Refrin
Fugan
Liu Lijun
Tan Shinchun
Application Number:
JP2003578314A
Publication Date:
June 17, 2009
Filing Date:
January 21, 2002
Export Citation:
Assignee:
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences PLA
International Classes:
C07C211/08; A61K31/13; A61K31/131; A61K31/132; A61K31/136; A61K31/137; A61K31/16; A61K31/165; A61K31/18; A61K31/405; A61K31/455; A61P1/06; A61P3/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P13/06; A61P17/12; A61P25/00; A61P25/08; A61P25/24; A61P25/28; A61P43/00; C07B61/00; C07C209/04; C07C209/28; C07C211/09; C07C211/17; C07C211/21; C07C211/27; C07C213/04; C07C215/08; C07C231/02; C07C233/11; C07C235/34; C07C237/06; C07C237/20; C07C243/02; C07C303/38; C07C311/16; C07D209/20; C07D213/82
Domestic Patent References:
| JP48036129A | ||||
| JP3204855A |
Foreign References:
| GB1574477B | ||||
| US3067101 | ||||
| GB873780B | ||||
| WO1995022327A1 | ||||
| WO2000037474A1 | ||||
| US3168567 |
Other References:
Chemical Abstracts,vol.61,abs.no.6908b-h
Chemical Abstracts,vol.59,abs.no.15808c-f
Chemical Abstracts,vol.75,abs.no.47363
Farmakologiya I Toksikologiya (Moscow),(1962),25,p.151-60
Angew. Chem. ,(1960),72,p.1001
Journal of MedicinaL and Pharmaceutical Chemistry,(1962),5(4)1962,p.665-690
Chemical Abstracts,vol.59,abs.no.15808c-f
Chemical Abstracts,vol.75,abs.no.47363
Farmakologiya I Toksikologiya (Moscow),(1962),25,p.151-60
Angew. Chem. ,(1960),72,p.1001
Journal of MedicinaL and Pharmaceutical Chemistry,(1962),5(4)1962,p.665-690
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda