Title:
ANALYSIS OF ELASTIC FIBER DAMAGE MARKER
Document Type and Number:
Japanese Patent JP2019066481
Kind Code:
A
Abstract:
To provide a method for measuring the amount of the marker for the elastic fiber damages in a sample.SOLUTION: The method includes the steps of: bringing a contact into contact with a compound of a specific expression; and executing mass spectrometry on the sample in contact with the compound of the specific expression. The present invention also provides: a method for diagnosing to find whether a subject has a disease characterized by presenting elastic fiber damages; a method for improving the accuracy and the precision of the mass spectrometry analysis of the marker for elastic fiber damages; and a kit for determining the amount of the marker for elastic fiber damages in a sample derived from the subject by a mass spectrometry. The present invention also provides a method for preventing progress of actions related to alpha-1 antitrypsin deficiency (AATD) of a subject having a normal lung function.SELECTED DRAWING: Figure 1
Inventors:
USUKI TOYONOBU
Application Number:
JP2018206695A
Publication Date:
April 25, 2019
Filing Date:
November 01, 2018
Export Citation:
Assignee:
TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
SOPHIA SCHOOL CORP
SOPHIA SCHOOL CORP
International Classes:
G01N27/62; A61K38/57; A61K45/00; A61P11/00; A61P43/00; G01N33/68
Domestic Patent References:
| JP2011510297A | 2011-03-31 |
Other References:
JENS LAMERZ, ANALYTICAL BIOCHEMISTRY, vol. 436, JPN6019045419, 2013, pages 127 - 136, ISSN: 0004317489
MICHIEL SPANBROEK, CHEST, vol. 141, no. 4, JPN7019003780, 2012, pages 1119 - 1120, ISSN: 0004317490
HIROTO YANUMA, TETRAHEDRON LETTERS, vol. 53, JPN6019045420, 2012, pages 5920 - 5922, ISSN: 0004317491
TOYONOBU USUKI, CHEM. COMMUN., vol. 48, JPN6019045421, 2012, pages 3233 - 3235, ISSN: 0004317492
MANOUCHEHR SALJOUGHIAN, JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 25, no. 3, JPN6019045422, 1988, pages 313 - 328, ISSN: 0004317493
TAKANORI KURITA, CHEM. EUR. J., vol. 14, JPN6019045424, 2008, pages 3371 - 3379, ISSN: 0004317494
HENRY RAKOFF, LIPIDS, vol. 27, no. 7, JPN6019045423, 1992, pages 567 - 569, ISSN: 0004317495
MICHIEL SPANBROEK, CHEST, vol. 141, no. 4, JPN7019003780, 2012, pages 1119 - 1120, ISSN: 0004317490
HIROTO YANUMA, TETRAHEDRON LETTERS, vol. 53, JPN6019045420, 2012, pages 5920 - 5922, ISSN: 0004317491
TOYONOBU USUKI, CHEM. COMMUN., vol. 48, JPN6019045421, 2012, pages 3233 - 3235, ISSN: 0004317492
MANOUCHEHR SALJOUGHIAN, JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 25, no. 3, JPN6019045422, 1988, pages 313 - 328, ISSN: 0004317493
TAKANORI KURITA, CHEM. EUR. J., vol. 14, JPN6019045424, 2008, pages 3371 - 3379, ISSN: 0004317494
HENRY RAKOFF, LIPIDS, vol. 27, no. 7, JPN6019045423, 1992, pages 567 - 569, ISSN: 0004317495
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hiroaki Oshima
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hiroaki Oshima
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