Title:
Anti-CD40 antibody, use, and method
Document Type and Number:
Japanese Patent JP6324891
Kind Code:
B2
Abstract:
The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1x10 -10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.
Inventors:
Peter Bo Yoakim Elmark
Eva Maria Darren
Eva Maria Darren
Application Number:
JP2014527743A
Publication Date:
May 16, 2018
Filing Date:
September 05, 2012
Export Citation:
Assignee:
Alligator Bioscience Arb
International Classes:
C12N15/09; A61K31/7088; A61K39/395; A61P35/00; A61P35/02; A61P43/00; C07K16/28; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP2008509080A |
Foreign References:
| WO2002088186A1 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
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