Title:
Anti-alpha 2 integrin antibodies and those use
Document Type and Number:
Japanese Patent JP5972176
Kind Code:
B2
Abstract:
The invention relates to antibodies directed to α2β1 integrin and their uses, including humanized anti-alpha 2 (α2) integrin antibodies and methods of treatment with anti-α2integrin antibodies. More specifically the present invention relates to humanized anti-α2 integrin antibodies comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG1 heavy chain constant region which exhibit altered effector function
Inventors:
Stanisla Blanc
Samuel Howe
Darko Skeguro
Samuel Howe
Darko Skeguro
Application Number:
JP2012554433A
Publication Date:
August 17, 2016
Filing Date:
February 22, 2011
Export Citation:
Assignee:
SANOFI
International Classes:
A61K39/395; C12N15/09; A61P1/04; A61P3/10; A61P9/00; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P43/00; C07K16/18; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2012518404A | ||||
| JP2009516506A |
Foreign References:
| US20070141052 | ||||
| US20070009523 |
Other References:
NATSUME A. et al.,Cancer Res,2008年,Vol.68, No.10,P.3863-3872
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi