Title:
ANTI-HER3/HER4 ANTIGEN BINDING PROTEINS THAT BIND TO BETA HAIRPIN OF HER3 AND BETA HAIRPIN OF HER4
Document Type and Number:
Japanese Patent JP2018068298
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4 both being hidden epitopes of the receptors, methods for selecting these antigen binding proteins, and methods of their preparation and use as medicament.SOLUTION: The invention provides an antigen binding protein that binds within a specific amino acid sequence of PQPLVYNKLTFQLEPNPHT of human HER3 and a specific amino acid sequence of PQTFVYNPTTFQLEHNFNA of human HER4. The antigen binding protein binds to β hairpin region of HER3 and/or binds to HER3-ECD with a ratio of the association constant in the presence of heregulin (Ka+) and the association constant in the absence of heregulin (Ka-)(Ka+/Ka-) being 4.0 or higher, and binds to β hairpin region of HER4 and/or binds to HER4-ECD with a ratio of the association constant in the presence of heregulin (Ka+) and the association constant in the absence of heregulin (Ka-)(Ka+/Ka-) being 20.0 or higher.SELECTED DRAWING: Figure 2
Inventors:
BIRGIT BBOSSENMAIER
GUY GEORGES
MICHAEL GERG
GERHARD NIEDERFELLNER
CHRISTIAN SCHOLZ
MICHAEL SCHRAEML
GUY GEORGES
MICHAEL GERG
GERHARD NIEDERFELLNER
CHRISTIAN SCHOLZ
MICHAEL SCHRAEML
Application Number:
JP2017213776A
Publication Date:
May 10, 2018
Filing Date:
November 06, 2017
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP2009102320A | 2009-05-14 | |||
| JP2004534831A | 2004-11-18 | |||
| JP2011505811A | 2011-03-03 | |||
| JP2015536336A | 2015-12-21 |
Foreign References:
| WO2012022814A1 | 2012-02-23 | |||
| WO2013084148A2 | 2013-06-13 |
Other References:
SCIENCE, vol. vol.297, p.1330-1333, JPN6018034865, 2002, US, ISSN: 0004138722
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation
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