Title:
抗ヒトパピローマウイルス１６ Ｅ６ Ｔ細胞受容体
Document Type and Number:
Japanese Patent JP6628719
Kind Code:
B2
Abstract:
Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
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Inventors:
Hinriks, Christian S.
Rosenberg, Stephen A.
Rosenberg, Stephen A.
Application Number:
JP2016527006A
Publication Date:
January 15, 2020
Filing Date:
July 14, 2014
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C07K14/725; A61K35/76; A61K39/395; A61K48/00; A61P31/20; A61P35/00; C07K16/00; C07K16/28; C07K19/00; C12N5/10; C12N15/13; C12N15/62; C12N15/63; C12Q1/02; G01N33/569; G01N33/574
Domestic Patent References:
| JP10509948A | ||||
| JP2013505734A |
Foreign References:
| WO2007131092A1 |
Other References:
Scholten et al.,Cellular Oncology,2010年,Vol.32, No.1-2,p.43-56
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma