Title:
細胞の細胞質に浸透して細胞内活性化されたＲＡＳを抑制する抗体及びその用途
Document Type and Number:
Japanese Patent JP2021509020
Kind Code:
A
Abstract:
本開示による修飾された重鎖可変領域および軽鎖可変領域の組み合わされた腫瘍特異的サイトゾル内在化ＲＡＳ抗体は高い生産収率により治療薬への開発を促進し、サイトゾルへの腫瘍特異的な内在化により変異型ＲＡＳを効果的に抑制できる。従って、単独の薬剤、または既存の薬剤との組み合わせで、効果的な腫瘍抑制活性が期待される。【選択図】 図１７Ａ
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Inventors:
Kim Yong Sung
Choi Dong Ki
Shin Sung Min
Park Song Wook
Choi Dong Ki
Shin Sung Min
Park Song Wook
Application Number:
JP2020545033A
Publication Date:
March 18, 2021
Filing Date:
November 16, 2018
Export Citation:
Assignee:
ORUM THERAPEUTICS INC.
International Classes:
C12N15/13; A61K39/395; A61P35/00; C07K16/18; C12N15/63; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JP2017529870A | 2017-10-12 |
Other References:
SEUNG-MIN SHIN ET AL.: "Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic adm", NATURE COMMUNICATIONS, JPN6021032076, 10 May 2017 (2017-05-10), ISSN: 0004722593
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 24, no. 3, JPN6021032082, 7 January 2014 (2014-01-07), pages 408 - 420, ISSN: 0004572883
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 24, no. 3, JPN6021032082, 7 January 2014 (2014-01-07), pages 408 - 420, ISSN: 0004572883
Attorney, Agent or Firm:
Kenjiro Yamaguchi
Kenichi Morita
Kenichi Morita