Title:
VLA-1に対する抗体
Document Type and Number:
Japanese Patent JP4303475
Kind Code:
B2
Abstract:
Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
Inventors:
Line, Paul Dee.
Gerber, Ellen Aye.
Saldanha, Jose W.
Carpsus, michael
Gerber, Ellen Aye.
Saldanha, Jose W.
Carpsus, michael
Application Number:
JP2002582193A
Publication Date:
July 29, 2009
Filing Date:
April 12, 2002
Export Citation:
Assignee:
Biogen Idec MA Inc.
International Classes:
C07K16/28; A61K39/395; G01N33/50; A61K49/16; A61P29/00; A61P37/00; C07H21/04; C07K16/18; C07K16/24; C07K16/46; C12N1/00; C12N5/10; C12N5/12; C12N5/20; C12N5/22; C12N9/00; C12N15/07; C12N15/09; C12N15/11; C12N15/13; G01N33/15; G01N33/53; G01N33/543; G01N33/567; G01N33/577; G06F17/00; G06F17/30; H04N9/64; H04N13/02; H04N15/00; C12N
Domestic Patent References:
| JP8131185A |
Foreign References:
| US5391481 |
Other References:
Journal of Clinical Investigation,2000, Vol.105, No.6, pp.721-729
Tissue Antigens,1996, Vol.48, pp.47-51
Laboratory Investigation,1995, Vol.72, No.3, pp.367-375
Tissue Antigens,1996, Vol.48, pp.47-51
Laboratory Investigation,1995, Vol.72, No.3, pp.367-375
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita