To provide a method and a composition to reduce growth of microbial colonies including infections, and further provide a therapeutic composition, a method for treatment of infections, and a method for identifying other such compositions.
There is provided a chimera Tail Associated Muralytic Enzyme (TAME) polypeptide comprising muralytic domain (MD) and foreign cell binding domain (CBD) which binds to a target bacterium, the target bacterium showing reduced growth or no growth after brought into contact with the chimera TAME polypeptide. There is provided a method of treating a bacterial infection of a subject in need of the therapy comprising the step of administering a pharmaceutical composition comprising the chimera TAME polypeptide to the subject.
VIVEK DANIEL PAUL
SARAVANAN R SANJEEV
SRIRAM BHARATHI
| WO1997008553A1 | 1997-03-06 | |||
| WO1997008553A1 | 1997-03-06 |
JPN6012059487; Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ Ｖｏｌ．１５， Ｎｏ．１８, 1996, ｐ．４７８９-４７９７
JPN6012059490; 生物工学会誌 Ｖｏｌ．８０， Ｎｏ．８, 2002, ｐ．３４４
JPN6012059491; 日本化学療法学会総会プログラム・講演抄録 Ｖｏｌ．５４ｔｈ, 20060420, ｐ．５８
JPN6012059494; 医薬ジャーナル Ｖｏｌ．４０， Ｎｏ．９, 2004, ｐ．２４５４-２４５９
JPN6012059496; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．９８， Ｎｏ．７, 2001, ｐ．４１０７-４１１２
JPN6012059498; 感染症学会誌 Ｖｏｌ．７８ 臨時増刊号, 2004, ｐ．５７
JPN6012059499; 空気清浄とコンタミネーションコントロール研究大会予稿集 Ｖｏｌ．１９ｔｈ, 2001, ｐ．３０３-３０５
JPN6012059486; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１７９， Ｎｏ．１１, 1997, ｐ．３６２５-３６３１
JPN6012059487; Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ Ｖｏｌ．１５， Ｎｏ．１８, 1996, ｐ．４７８９-４７９７
JPN6012059490; 生物工学会誌 Ｖｏｌ．８０， Ｎｏ．８, 2002, ｐ．３４４
JPN6012059491; 日本化学療法学会総会プログラム・講演抄録 Ｖｏｌ．５４ｔｈ, 20060420, ｐ．５８
JPN6012059494; 医薬ジャーナル Ｖｏｌ．４０， Ｎｏ．９, 2004, ｐ．２４５４-２４５９
JPN6012059496; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．９８， Ｎｏ．７, 2001, ｐ．４１０７-４１１２
JPN6012059498; 感染症学会誌 Ｖｏｌ．７８ 臨時増刊号, 2004, ｐ．５７
JPN6012059499; 空気清浄とコンタミネーションコントロール研究大会予稿集 Ｖｏｌ．１９ｔｈ, 2001, ｐ．３０３-３０５
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
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