Title:
ANTIMICROBIAL AGENTS
Document Type and Number:
Japanese Patent JP2017008033
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide antimicrobial agents with enhanced activity against Gram-negative bacteria for use as a medical agents for treatment or prevention of Gram-negative bacterial infections, as diagnostic means, or as cosmetic materials, further for the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.SOLUTION: The invention provides an antimicrobial agent against Gram-negative bacteria, in particular, a fusion protein comprising an enzyme having an activity to degrade Gram-negative bacterial cell wall and a peptide stretch fused to the N- or C-terminus of the enzyme, as well as a nucleic acid molecule encoding the fusion protein, a vector comprising the nucleic acid molecule and a host cell comprising either the nucleic acid or the vector.SELECTED DRAWING: None
Inventors:
LAVIGNE ROB
MILLER STEFAN
BRIERS YVES
VOLCKAERT GUIDO
WALMAGH MAARTEN
MILLER STEFAN
BRIERS YVES
VOLCKAERT GUIDO
WALMAGH MAARTEN
Application Number:
JP2016113291A
Publication Date:
January 12, 2017
Filing Date:
June 07, 2016
Export Citation:
Assignee:
UNIV LEUVEN KATH
LYSANDO HOLDING AG
LYSANDO HOLDING AG
International Classes:
C07K19/00; A23L3/3571; A61K8/64; A61K8/66; A61K38/00; A61K38/46; A61P1/04; A61P1/16; A61P11/00; A61P11/02; A61P11/08; A61P13/02; A61P17/00; A61P17/02; A61P19/08; A61P25/00; A61P27/02; A61P27/16; A61P31/00; A61P31/04; A61Q19/00; C07K14/00; C12N1/19; C12N1/21; C12N9/24; C12N9/48; C12N15/09; G01N33/68
Domestic Patent References:
| JP2012516776A | 2012-07-26 | |||
| JPH10505592A | 1998-06-02 | |||
| JPH08501213A | 1996-02-13 | |||
| JP2006504400A | 2006-02-09 |
Foreign References:
| WO2009041830A2 | 2009-04-02 | |||
| WO2009068858A1 | 2009-06-04 |
Other References:
APPL. MICROBIOL. BIOTECHNOL., vol. 65, JPN6014046507, 2004, pages 105 - 109, ISSN: 0003696841
J BIOL CHEM., vol. 283, no. 11, JPN6014046508, 2008, pages 7242 - 7250, ISSN: 0003696842
CELL. MOL. LIFE SCI (2008) VOL.65, PP.1202-1219, JPN6017014647, ISSN: 0003696840
J BIOL CHEM., vol. 283, no. 11, JPN6014046508, 2008, pages 7242 - 7250, ISSN: 0003696842
CELL. MOL. LIFE SCI (2008) VOL.65, PP.1202-1219, JPN6017014647, ISSN: 0003696840
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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