Title:
ヒトのアセチルコリンエステラーゼ(ACHE)に対するアンチセンスオリゴヌクレオチド及びその使用
Document Type and Number:
Japanese Patent JP4316373
Kind Code:
B2
Abstract:
The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or prevention of neuromuscular disorders, preferably myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
Inventors:
Solek Hermona
Application Number:
JP2003509100A
Publication Date:
August 19, 2009
Filing Date:
May 23, 2002
Export Citation:
Assignee:
Ism Research Development Company of the Hebrew University of Jerusalem
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P21/00; A61P21/02; A61P21/04; A61P25/00; C12N15/113; A61K38/00
Domestic Patent References:
| JP8804083A |
Foreign References:
| WO1998026062A1 | ||||
| WO1998022132A1 | ||||
| WO2001036627A1 | ||||
| EP0388906A1 |
Other References:
Proc. Natl. Acad. Sci. USA,1990年,Vol.87,pp.9688-9692
Attorney, Agent or Firm:
Keiki Tanabe