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Title:
APO-2 LIGAND
Document Type and Number:
Japanese Patent JP2010246560
Kind Code:
A
Abstract:

To provide a new cytokine which is not inhibited enough to be sensible by Fas/Apo-1, TNF-R1 or TNF-R2 receptors, etc.

The new cytokine, designated as Apo-2 ligand, which induces mammalian cancer cell apoptosis, is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acids encoding the Apo-2 ligand, and antibodies to the Apo-2 ligand are also provided. Further, a method for using the Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are provided.


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Inventors:
ASHKENAZI AVI J
KELLEY ROBERT F
O'CONNEL MARK T
PITTI ROBERT M
SCHWALL RALPH H
Application Number:
JP2010151519A
Publication Date:
November 04, 2010
Filing Date:
July 02, 2010
Export Citation:
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Assignee:
GENENTECH INC
International Classes:
C12N15/09; A61K38/00; A61P35/00; A61P43/00; C07K14/52; C07K14/525; C07K14/705; C07K16/24; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02
Foreign References:
WO1997001633A11997-01-16
WO1997025428A11997-07-17
Other References:
JPN6012037295; Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，１９９６　Ｍａｙ　３１，２７１（２２），ｐ．１２６８７-９０
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori



 
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