Title:
芳香族1,4-ジ-カルボキシルアミド及びその使用
Document Type and Number:
Japanese Patent JP2010512357
Kind Code:
A
Abstract:
The invention relates to novel compounds of formula I Wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R 1 , R 2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C 1 -C 3 alkyl group and a C 1 -C 3 alkoxy group, R 3 represents, independently from one another if p is not 0, hydrogen, halogen, a C 1 -C 5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C 1 -C 4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C 1 -C 3 alkyl, a hydroxyl or a benzyl group, a C 1 -C 6 alkylsulfonyl, a mono or disubstituted C 1 -C 5 alkyl group, a branched or a cyclic amine, R 6 is H or part of a alicyclic,heteroalicyclic ring system, if m is 0 then C represents CF 3 or a branched or unbranched C 1 -C 4 alkyl group, if m = 1 then C represents -CH 2 -O-, -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH 2 (CH 2 )CH 2 - or denotes a chemical bond between N-C or C-C, the CONR 6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R 3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4-thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer.
Inventors:
Gabriel, Garcia
Durham, Pierre
Froche, Barbara
Remylet, Guy
Scapozza, Leonardo
Durham, Pierre
Froche, Barbara
Remylet, Guy
Scapozza, Leonardo
Application Number:
JP2009540651A
Publication Date:
April 22, 2010
Filing Date:
December 11, 2007
Export Citation:
Assignee:
THE GENETICS COMPANY,INC.
International Classes:
C07C233/75; A61K31/167; A61K31/196; A61K31/245; A61K31/277; A61K31/37; A61K31/44; A61K31/444; A61K31/455; A61K31/505; A61K31/5377; A61P17/02; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07C233/81; C07C235/64; C07C235/84; C07C237/42; C07D213/75; C07D213/82; C07D239/26; C07D311/14; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14
Attorney, Agent or Firm:
Noboru Fujimoto
Seiichi Yakumaru
Hiroaki Nakatani
Yuichi Koyama
Seiichi Yakumaru
Hiroaki Nakatani
Yuichi Koyama