Title:
オートタキシンの置換スピロ環式阻害剤
Document Type and Number:
Japanese Patent JP6616821
Kind Code:
B2
Abstract:
The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
Inventors:
Babis, Lee
Clark, Matthew
Keef, Antony Dee.
Marvi Hill, Mark Jay.
D, Hai Phong
Rensetti, Lewis
Frank Rubesome
One, Tse
Chie, diphen
Zan, Inn
Clark, Matthew
Keef, Antony Dee.
Marvi Hill, Mark Jay.
D, Hai Phong
Rensetti, Lewis
Frank Rubesome
One, Tse
Chie, diphen
Zan, Inn
Application Number:
JP2017503794A
Publication Date:
December 04, 2019
Filing Date:
April 03, 2015
Export Citation:
Assignee:
X-R-X, Inc.
International Classes:
C07D471/10; A61K31/438; A61K31/444; A61K31/498; A61K31/506; A61K31/538; A61K45/00; A61P1/16; A61P7/02; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P19/02; A61P25/04; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/06; A61P43/00; C07D498/10; C07D519/00
Domestic Patent References:
| JP2004532838A |
Foreign References:
| WO2010037081A1 | ||||
| US20120302540 | ||||
| US20110212882 | ||||
| WO2005122379A2 |
Other References:
PUBCHEM.[online],2012年,CID 56755867,CID 56755867. March 08.2012,pp1-2 [0nline]https://pubchem.ncbi.nlm.nih.gov/compound/56755867
PUBCHEM.[online],2012年,CID 55023722,CID 55023722.January 24.2012,pp1-2 [0nline]https://pubchem.ncbi.nlm.nih.gov/compound/55023722
PUBCHEM.[online],2012年,CID 55023722,CID 55023722.January 24.2012,pp1-2 [0nline]https://pubchem.ncbi.nlm.nih.gov/compound/55023722
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto