AXIALLY CHIRAL ISOQUINOLINE DERIVATIVE, ITS PRODUCTION METHOD, AND ASYMMETRIC SYNTHESIS METHOD

Title:

AXIALLY CHIRAL ISOQUINOLINE DERIVATIVE, ITS PRODUCTION METHOD, AND ASYMMETRIC SYNTHESIS METHOD

Document Type and Number:

Japanese Patent JP2012031119

Kind Code:

A

Abstract:

To provide a method for producing an isoquinoline derivative, useful as a ligand or a nucleophilic catalyst, without going through optical resolution, but with a simple process.

The process for obtaining an axially chiral isoquinoline derivative represented by formula (3) includes reacting a compound of formula (1) and a compound of formula (2) at the presence of a catalyst containing a rhodium metal or an optically active bisphosphine (Q: =N- and the like; Z: O and the like).

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Inventors:

TANAKA TAKESHI

Application Number:

JP2010173558A

Publication Date:

February 16, 2012

Filing Date:

August 02, 2010

Export Citation:

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Assignee:

UNIV TOKYO AGRICULTURE & TECHNOLOGY

International Classes:

C07D401/04; C07D405/04; C07F7/08; C07F7/10; C07F9/50; C07F9/53; C07B61/00

Attorney, Agent or Firm:

Atsushi Nakajima
Kato Kazunori
Hiroshi Fukuda

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