(Aza -) Isoquinolinone derivative - Merck Patent Gesellschaft mit beschraenkter Haftung

Title:

(Aza -) Isoquinolinone derivative

Document Type and Number:

Japanese Patent JP6247294

Kind Code:

B2

Abstract:

Compounds of the formula I in which R1, X, Y and n have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

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Inventors:

Dolsh Dieter
Buchstaller, Hans-Peter

Application Number:

JP2015525763A

Publication Date:

December 13, 2017

Filing Date:

July 12, 2013

Export Citation:

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Assignee:

Merck Patent Gesellschaft mit beschraenkter Haftung

International Classes:

C07D471/04; A61K31/4375; A61P9/00; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P43/00

Domestic Patent References:

JP2000053647A
JP2002511888A
JP2005533028A
JP2010509359A

Foreign References:

WO2011107709A1
US20080188467

Other References:

CHO WON-JEA,SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-ARYLISOQUINOLINES AS ANTITUMOR AGENTS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,1998年 1月 6日,V8 N1-6,P41-46
SEUNG HOON CHEON,STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF ISOQUINOLINONE TYPE ANTICANCER AGENT,ARCHIVES OF PHARMACOL RESEARCH,KR,2001年,V24 N4,P276-280

Attorney, Agent or Firm:

Kiyoji Kuzuwa

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