NEW MATERIAL:The compound of formula I [R1 is (substituted) phenyl; R2 is carboxyl-protecting group; X is H or Cl; Y is I, ONO2, OH, group of formula IIWIV, or SR4; R3 is lower alkyl or OR5 (R5 is halogen-containing lower alkyl); R4 is (substituted) S- or N-containing 5-membered hetrocyclic group].
EXAMPLE: 2-( 3-Phenyldichloromethyl- 7- oxo-4-thia-2, 6-diazabicyclo[ 3,2,0 ]-hept- 2-en-6-yl)-3-ethoxythiocarbonylthiomethyl-3-butenoic acid methyl ester.
USE: Synthetic intermediate of cephalosporin-type antibiotic substance useful as an antibacterial agent.
PROCESS: The compound of formula V is made to react with the nucleophilic agent of formula M-Y (M is Na or K; Y is I or group of formula III) in an organic solvent such as acetone, dimethyl sulfoxide, etc. preferably at 10W55°C for 0.5W4hr.
TANAKA HIDEO
NOGAMI JIYUNZOU
SASAOKA MICHIO
SHIROI TAKASHI
SAITOU NORIO
| JPS5759896A | 1982-04-10 | |||
| JPS5143791A | 1976-04-14 |