Title:
カチオン性アルファアミノ酸を含有する生分解性ポリマー遺伝子導入組成物
Document Type and Number:
Japanese Patent JP2010536884
Kind Code:
A
Abstract:
The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as arginine or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.
More Like This:
Inventors:
Turnell, William, Gee.
Cruz-Aranda, Gina, Anne
Woo, mark, mince
Chan Tan, Ronald, Lee
Gom Rashvili, Zaza, Dee.
Defife, Christine, M.
Cruz-Aranda, Gina, Anne
Woo, mark, mince
Chan Tan, Ronald, Lee
Gom Rashvili, Zaza, Dee.
Defife, Christine, M.
Application Number:
JP2010522076A
Publication Date:
December 02, 2010
Filing Date:
August 22, 2008
Export Citation:
Assignee:
Medibus LLC
International Classes:
A61K48/00; A61K31/7105; A61K47/34; C08G69/10; C12N15/11; C12N15/87
Foreign References:
| WO2006088647A1 | 2006-08-24 |
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Ikeda adult
Masakazu Noda
Yoshinori Shimizu
Ikeda adult