Title:
早産を予測するためのバイオマーカーおよび方法
Document Type and Number:
Japanese Patent JP7412790
Kind Code:
B2
Abstract:
The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preterm birth relative to matched controls. The present disclosure is further based, in part, on the unexpected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preterm birth in a pregnant female with relatively high sensitivity and specificity. These proteins and peptides disclosed herein serve as biomarkers for classifying test samples, predicting a probability of preterm birth, monitoring of progress of preterm birth in a pregnant female, either individually or in a panel of biomarkers.
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Inventors:
Darling Edward Hickock
John Jay Boniface
Gregory Charles Clitchfield
Tracy Christine Frascher
John Jay Boniface
Gregory Charles Clitchfield
Tracy Christine Frascher
Application Number:
JP2022032552A
Publication Date:
January 15, 2024
Filing Date:
March 03, 2022
Export Citation:
Assignee:
Cera Prognostics, Incorporated
International Classes:
G01N33/53; C07K7/06; C07K7/08; C07K14/47; C40B40/10; G01N27/62
Domestic Patent References:
| JP2007506979A |
Foreign References:
| US20110020836 |
Other References:
Caroline L. Stella, MD et al.,American Journal of Obstetrics & Gynecology,2009年,Vol.201, No.387,e1-13.
G. G. Klee et al.,Clinical Chemistry,2012年,Vol.58, No.10 Supplement,A77,B-103
G. G. Klee et al.,Clinical Chemistry,2012年,Vol.58, No.10 Supplement,A77,B-103
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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