Title:
BIOMARKERS FOR TREATMENT OF PSORIASIS
Document Type and Number:
Japanese Patent JP2016185151
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis, and prediction methods using the markers.SOLUTION: A method of predicting whether a patient is responsive to a treatment for psoriasis comprises: obtaining cells from the patient; culturing the cells in the presence or absence of a treatment compound; measuring the level of a cell marker selected from CD11c, CD3, CD56, ICAM-1, Foxp3, HLA-DR and combinations thereof; and comparing the level of the cell marker in the cells cultured in the presence of the treatment compound to the level of the cell marker in the cells cultured in the absence of the treatment compound; where a decreased level of the cell marker in the presence of the treatment compound indicates the likelihood of an effective patient response to the treatment compound.SELECTED DRAWING: None
Inventors:
PETER H SCHAFER
LIN YONG
DONNA SUTHERLAND
LIN YONG
DONNA SUTHERLAND
Application Number:
JP2016101189A
Publication Date:
October 27, 2016
Filing Date:
May 20, 2016
Export Citation:
Assignee:
CELGENE CORP
International Classes:
C12Q1/02; A61K31/4035; A61K45/00; A61P17/06; C12M1/00; C12N15/09; C12Q1/68
Domestic Patent References:
| JP2009521933A | 2009-06-11 |
Foreign References:
| US20080234359A1 | 2008-09-25 | |||
| WO2009120167A1 | 2009-10-01 | |||
| WO2009120296A1 | 2009-10-01 | |||
| WO2009063897A1 | 2009-05-22 |
Other References:
BR. J. PHARMACOL., 2010, 159(4), PP.842-855, JPN6015018914, ISSN: 0003898756
PROC. NATL. ACAD. SCI. U S A, 2005, 102(52), PP.19057-19062, JPN6015018915, ISSN: 0003569956
PROC. NATL. ACAD. SCI. U S A, 2005, 102(52), PP.19057-19062, JPN6015018915, ISSN: 0003569956
Attorney, Agent or Firm:
Toru Ishikawa