Title:
ビスアリールスルホンアミド化合物及び癌の治療におけるその使用
Document Type and Number:
Japanese Patent JP2006508906
Kind Code:
A
Abstract:
The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C1-5 branched or unbranched alkyl group or a C2-5 alkenyl group; n is 0 or 1; R1 is H, a C1-8 branched or unbranched alkyl group, a C2-8 alkenyl group, or an aryl or aralkyl group; Ar1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.
Inventors:
Wang Su Dong
Gibson Darren
Duncan Kennis
Bailey kevin
Thomas mark
McCallum David
Zereva Daniella
Turner Nicolas John
Fisher Peter Martin
Gibson Darren
Duncan Kennis
Bailey kevin
Thomas mark
McCallum David
Zereva Daniella
Turner Nicolas John
Fisher Peter Martin
Application Number:
JP2004518989A
Publication Date:
March 16, 2006
Filing Date:
July 07, 2003
Export Citation:
Assignee:
Cyclacel Limited
International Classes:
A61K31/18; A61K31/381; A61K31/40; A61K31/4045; A61K31/415; A61K31/4155; A61K31/4184; A61K31/421; A61K31/426; A61K31/429; A61K31/43; A61K31/433; A61K31/44; A61K31/4439; A61K31/454; A61K31/506; A61K31/537; A61K31/5377; A61K31/7048; A61K33/24; A61K45/00; A61P9/10; A61P11/00; A61P13/12; A61P17/06; A61P17/14; A61P29/00; A61P33/06; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C311/21; C07C311/29; C07C311/42; C07C311/44; C07D207/36; C07D209/14; C07D209/16; C07D213/70; C07D213/71; C07D231/12; C07D235/30; C07D263/32; C07D277/20; C07D277/56; C07D285/06; C07D285/14; C07D295/185; C07D319/18; C07D333/34; C07D333/42; C07D333/62; C07D409/04; C07D409/12; C07D513/04; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Masaki Hirota