BORDETELLA PARAPERTUSSIS WHOLE-CELL VACCINE COMPOSITION

Japanese Patent JP2013216683

A

To provide a whole cell bacteria vaccine composition for preventing pertussis originated from Bordetella parapertussis, which contains a whole cell of Bordetella parapertussis, a homogenate of the whole cell or a cell lysate, as an immunogen, and to provide a production method thereof.

Bordetella parapertussis is cultured under the conditions of 37°C and three days, and thereafter inactivated by adjusting the cell concentration to 10¹⁰ cells/mL and adding a formaldehyde solution such that the final concentration of formalin is 0.2%. The cell is adjusted to 10¹⁰ cells/mL in terms of cell density by adding sterile phosphate-buffered saline, to give a vaccine composition.

WATANABE MINEO
KOMATSU EIJI

JP2013135175A

October 24, 2013

June 27, 2013

Click for automatic bibliography generation  

KITASATO DAIICHI SANKYO VACCINE CO LTD

A61K39/10; A61P31/04

JP2004250346A	2004-09-09
JP5398527B2	2014-01-29

JPN6008033172; ＳＡＲＡＮ，Ｇ．　ｅｔ　ａｌ，　Ｓｅｒｏｌｏｇｉｃａｌ　ａｎｄ　ｐｒｏｔｅｃｔｉｖｅ　ａｃｔｉｖｉｔｉｅｓ　ｏｆ　ｐｅｒｔｕｓｓｉｓ，　ｐａｒａｐｅｒｔｕｓｓｉｓ，　ａｎｄ　ｂｒｏｎｃｈｉｓｅｐｔｉｃ
JPN6008033174; ＫＯＨＬＥＲ-ＫＵＢＥＩＫＡ，Ｎ．，　Ｎｏ　Ｅｎｇｌｉｓｈ　Ｔｉｔｌｅ　Ａｖａｉｌａｂｌｅ．　　Ｏｒｉｇｉｎａｌ　Ｔｉｔｌｅ：　Ｄｉｐｈｔｈｅｒｉａ-ｔｅｔａｎｕｓ-ｐｅｒｔｕｓｓｉｓ　ｖａｃｃｉｎｅ

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

Previous Patent: FILM AND FILM-FORMING COMPOSITION

Next Patent: ANTHRACENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME