Title:
末梢感覚求心性機能を修正させ得るボツリヌス毒素誘導体
Document Type and Number:
Japanese Patent JP4304241
Kind Code:
B2
Abstract:
A novel agent for the targeted control of a mammalian cell activity can be used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E, linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain, which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome; Domain T is the Translocation Domain, which translocates the agent from within the endosome across the endosomal membrane into the cytosol of the cell; and Domain E is the Effector Domain, which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.
Inventors:
Foster, keith, alan
Dagan, Michael, John
Shawn, Clifford, Charles
Dagan, Michael, John
Shawn, Clifford, Charles
Application Number:
JP53154696A
Publication Date:
July 29, 2009
Filing Date:
April 16, 1996
Export Citation:
Assignee:
Syntaxin Limited
International Classes:
A61K38/46; A61K35/74; C12N15/09; A61K38/00; A61K38/16; A61K38/22; A61K38/27; A61K38/48; A61K39/395; A61K47/48; A61P25/00; A61P25/04; C07K14/33; C07K14/48; C07K19/00; C12N9/52; C12N15/31; C12N15/62; C12P21/02
Domestic Patent References:
| JP6303987A | ||||
| JP9503486A | ||||
| JP8508241A | ||||
| JP60069033A |
Attorney, Agent or Firm:
Hiromichi Nanjo
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