Title:
CALCITRIOL INTERMEDIATE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP2929943
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new S-5-hydroxy-octa-2,7-diyn-1-ol compound useful as a raw material compound capable of efficiently and simply providing an important intermediate corresponding to a part of ring A for producing a therapeutic agent calcitriol for osteoporosis, etc.
CONSTITUTION: This compound is expressed by formula I (R1 is H or trimethylsilyl; R2 is H or t-butydimethylsilyl; R3 is H or tetrahydropyranyl), e.g. a compound of formula II (TMS is trimethylsilyl; THP is tetrahydropyranyl). The exemplified compound of formula II is obtained by reacting S-5- trimethylsilyl-1,2-oxiranylpent-4-yne of formula III with propargyl tetrahydropyranyl ether and n-butyl-lithium.
Inventors:
OGASAWARA KUNIRO
TAZUMI KOGETSU
TAZUMI KOGETSU
Application Number:
JP21394494A
Publication Date:
August 03, 1999
Filing Date:
September 07, 1994
Export Citation:
Assignee:
DAISOO KK
International Classes:
C07D303/20; C07C29/56; C07C33/04; C07D309/12; C07F7/08; C07F7/18; (IPC1-7): C07C33/04; C07C29/56; C07D309/12; C07F7/08; C07F7/18
Domestic Patent References:
| JP820590A |
Other References:
【文献】畑山範 ”活性型ビタミンD▲下3▼A環部の簡便合成法の開発”日本薬学会第114年講演要旨集2(平成6年3月5日発行)