To construct a vector specifically expressing and replicating a gene in a specific cell, to provide a DNA with gene expression control activity for use in constructing the vector, and to provide e.g. a method for treating a malignant tumor, or the like, by transferring the vector into a specific biological tissue or cell with the region and by expressing and replicating the gene.
This method for treating a malignant tumor comprises the steps of obtaining the transcription initiation control region of human calponin gene which is specifically expressed in a cell, linking the region to the upstream portion of a replication-related gene for a virus, integrating the resultant into a viral DNA to construct the objective cell-specific expression replication vector inert to a normal cell in an adult, transferring the vector into a malignant tumor cell, and thus selectively damaging the oncocyte or the proliferated smooth muscle cell of a neoplastic blood vessel.
YAMAMURA TOMOKO
MIYATAKE SHINICHI
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