PURPOSE: To obtain a new compound useful as an inhibitor of the synthesis of thromboxane A2, an antagonistic agent for the thromboxane A2 and prostaglandin H2, an antithrombotic agent and an antiallergic agent.
CONSTITUTION: This compound is expressed by the formula (n is 3 or 4; R is a 1-4C alkyl or H), e.g. 3-{4-[1-(4chlorobenzenesulfonylamido)-5-(3-pyridyl) pentan-2-yl]phenyl}propionic acid. The compound expressed by the formula is obtained by carrying out the aldol type reaction of 3-(3-pyridyl)acrolein with methyl p-cyanomethylcinnamate in the presence of a base such as an aqueous solution of sodium hydroxide, then dissolving the resultant adduct in a solvent such as ethyl acetate-methanol, as necessary, pressurizing the reactional solution, catalytically reducing the adduct in the presence of a catalyst such as Raney nickel, providing an amino derivative, then reacting the resultant amino derivative with p-chlorobenzenesuilonyl chloride in the presence of a base such as triethylamine and, as necessary, hydrolyzing the obtained reactional product.
TATSUGAMI SHINICHI
KASUKAWA HIROAKI
KITAMURA HARUE
MORIMOTO KATSUMI
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