Title:
脈絡膜新生血管抑制剤又はドルーゼン抑制剤およびその評価又はスクリーニング方法
Document Type and Number:
Japanese Patent JP6967222
Kind Code:
B2
Abstract:
The existent therapeutic drugs for CNV are merely pharmaceuticals for a symptomatic therapy, and therapeutic drugs for radical cure are strongly demanded. Also, a therapeutic drug for Dry AMD does not exist, and therapeutic drugs for radical cure are strongly demanded. The present invention provides a prophylactic and/or therapeutic agent for choroidal neovascularization, containing a compound having an activity of suppressing epithelial-mesenchymal transition in retinal pigment epithelial cells, as an active ingredient. Also, the present invention provides a drusen suppressor comprising a compound having an activity of suppressing epithelial-mesenchymal transition in retinal pigment epithelial cells, as an active ingredient.
Inventors:
Shinichiro Niwa
Ogura Dai
Hidemi Mizunuma
Yoko Arai
Takahiro Kurose
Yoshihiro Takai
Mitsuguchi Yoko
Moriya Banyo
Ogura Dai
Hidemi Mizunuma
Yoko Arai
Takahiro Kurose
Yoshihiro Takai
Mitsuguchi Yoko
Moriya Banyo
Application Number:
JP2017556480A
Publication Date:
November 17, 2021
Filing Date:
December 16, 2016
Export Citation:
Assignee:
Link Genomics Co., Ltd.
Rohto Pharmaceutical Co., Ltd.
Rohto Pharmaceutical Co., Ltd.
International Classes:
A61K31/421; A61K31/122; A61K31/192; A61K31/38; A61K31/381; A61K31/404; A61K31/41; A61K31/436; A61K31/47; A61P27/02; A61P43/00
Domestic Patent References:
| JP2009527580A | ||||
| JP2015535293A | ||||
| JP2008520547A | ||||
| JP2016539098A |
Foreign References:
| WO2015061658A1 | ||||
| US20090270490 |
Other References:
ZHOU X, et al.,Sulindac has strong antifibrotic effects by suppressing STAT3-related miR-21,J.Cell.Mol.Med.,2015年05月,Vol.19,No.5,p.1103-1113,Abstract
HIRASAWA M, et al.,Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovasculariz,Molecular Vision,2011年,Vol.17,p.1222-1230,Abstract,1222ページ右欄11-13行
HWANG KE, et al.,Down-regulated SIRT1 by Nonsteroidal Antiinflammatory Drugs is to Inhibit TGF-1 induced Epithelial-M,Chest,2015年10月,Vol.148,No.4 Meeting Abstract,548A,Abstract
Laboratory Investigation,91,2011年,1277-1290
鹿児島市医報 ,2004年,第43巻第5号,1ページ
HIRASAWA M, et al.,Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovasculariz,Molecular Vision,2011年,Vol.17,p.1222-1230,Abstract,1222ページ右欄11-13行
HWANG KE, et al.,Down-regulated SIRT1 by Nonsteroidal Antiinflammatory Drugs is to Inhibit TGF-1 induced Epithelial-M,Chest,2015年10月,Vol.148,No.4 Meeting Abstract,548A,Abstract
Laboratory Investigation,91,2011年,1277-1290
鹿児島市医報 ,2004年,第43巻第5号,1ページ
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office