Title:
ヒトにおける固形腫瘍の処置のためのＣ．ｎｏｖｙｉ
Document Type and Number:
Japanese Patent JP7445893
Kind Code:
B2
Abstract:
The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1 × 103-1 × 107 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided.
Inventors:
Saurabh Saha
Urinal elephant
Bert Vogelstein
Kenneth W. Kinsler
Urinal elephant
Bert Vogelstein
Kenneth W. Kinsler
Application Number:
JP2020109387A
Publication Date:
March 08, 2024
Filing Date:
June 25, 2020
Export Citation:
Assignee:
Biomed Valley Discoveries, Incorporated
The Johns Hopkins University
The Johns Hopkins University
International Classes:
A61K35/74; A61K9/10; A61K31/337; A61K31/4164; A61K31/424; A61K31/43; A61K31/436; A61K31/4995; A61K31/506; A61K31/65; A61K31/675; A61K31/7008; A61K31/7068; A61K39/395; A61K45/00; A61P35/00; A61P43/00
Foreign References:
| WO2003045153A1 | ||||
| WO2008073148A1 |
Other References:
1:Chetan Bettegowda et al.,Clostridium novyi-NT cancer therapeutic,Biomed Valley Discoveries ,Chordoma Foundation,2013年4月,p.1-42,http://www.chordomafoundation.org/wp-content/uploads/2013/04/2013-Bettegowda-Saha.pdf
Attorney, Agent or Firm:
Shusaku Yamamoto