Title:
高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング
Document Type and Number:
Japanese Patent JP7145083
Kind Code:
B2
Abstract:
Methods for improving transgene in chloroplasts are disclosed along with improved transgenes so produced and methods of use thereof for the treatment of disease. Specifically, the methods comprising analyzing the native sequence of a nucleic acid encoding a protein of interest and replacing codons in said sequence with those preferentially used in psbA genes in chloroplasts in higher plants.
Inventors:
Daniel Henry
Application Number:
JP2018568189A
Publication Date:
September 30, 2022
Filing Date:
March 20, 2017
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/82; A01H5/00; A61K8/66; A61K9/68; A61K36/28; A61K36/81; A61K38/47; A61K39/13; A61P1/02; A61P31/14; A61Q11/00; C07K14/105; C07K14/195; C12N9/24
Domestic Patent References:
| JP2002526116A | ||||
| JP10201483A | ||||
| JP63132844A |
Foreign References:
| US20110179530 | ||||
| US20060253935 |
Other References:
MURRAY, E. E. et al. ,Codon usage in plant genes,Nucleic Acids Res. ,1989年,Vol. 17, No. 2,P. 477-498
Ribosome Profiling Enables Comprehensive Translation Analysis,[online],illumina Application Note:Sequencing,2010年,[令和3年2月15日検索],インターネット
Ribosome Profiling Enables Comprehensive Translation Analysis,[online],illumina Application Note:Sequencing,2010年,[令和3年2月15日検索],インターネット
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes