COMPOSITION AND METHOD FOR TREATING INTRACELLULAR DISEASE

Japanese Patent JP2010116417

A

To provide a therapeutic agent for treating or preventing intracellular bacterial infection or parasitic infection, or a disease caused by an infectious agent such as a virus (e.g., hepatitis).

A method for treating intracellular infection includes the steps of: administering a vector construct which directs expression of at least one immunogenic portion of an antigen derived from an intracellular pathogen; and further administering a protein containing the immunogenic portion of the antigen to a warm-blooded animal to generate an immune response as the result.

SALLBERG MATTI
MILICH DAVID R
LEE WILLIAM T L

JP2010029555A

May 27, 2010

February 12, 2010

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NOVARTIS VACCINES & DIAGNOSTIC
SCRIPPS RESEARCH INST

A61K39/00; A61K31/711; C12N15/09; A61K35/76; A61K39/12; A61K39/21; A61K39/245; A61K39/29; A61K48/00; A61P31/00; A61P31/12; A61P31/14; A61P31/18; A61P31/20; C07K14/005; C07K14/02; C07K14/18; C12N15/36; C07K14/155

JPH07145079A	1995-06-06
JPH09512177A	1997-12-09

WO1992011028A1	1992-07-09
WO1996020732A2	1996-07-11
WO1996021416A2	1996-07-18
US5217879A	1993-06-08
US5091309A	1992-02-25

JPN6012027661; ＨＵ，Ｓ．Ｌ．　ｅｔ　ａｌ: 'Ｎｅｕｔｒａｌｉｚｉｎｇ　ａｎｔｉｂｏｄｉｅｓ　ａｇａｉｎｓｔ　ＨＩＶ-１　ＢＲＵ　ａｎｄ　ＳＦ２　ｉｓｏｌａｔｅｓ　ｇｅｎｅｒａｔｅｄ　ｉｎ　ｍｉｃｅ　ｉｍｍｕｎｉｚｅｄ　ｗｉｔｈ　ｒｅｃｏｍｂｉｎ' ＡＩＤＳ　ｒｅｓｅａｒｃｈ　ａｎｄ　ｈｕｍａｎ　ｒｅｔｒｏｖｉｒｕｓｅｓ Ｖｏｌ．７，　Ｎｏ．７, 1991, ｐ．６１５-６２０
JPN6012027664; ＤＡＶＩＳ，Ｈ．Ｌ．　ｅｔ　ａｌ: 'ＤＮＡ-ｍｅｄｉａｔｅｄ　ｉｍｍｕｎｉｚａｔｉｏｎ　ｔｏ　ｈｅｐａｔｉｔｉｓ　Ｂ　ｓｕｒｆａｃｅ　ａｎｔｉｇｅｎ：　ｌｏｎｇｅｖｉｔｙ　ｏｆ　ｐｒｉｍａｒｙ　ｒｅｓｐｏｎｓｅ　ａｎｄ　ｅｆｆｅｃｔ　ｏ' Ｖａｃｃｉｎｅ Ｖｏｌ．１４，　Ｎｏ．９, 199606, ｐ．９１０-９１５

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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