PURPOSE: To readily obtain the subject preparation having a simple composition and capable of controlling elusion of a medicine.
CONSTITUTION: In a preparation composed of a medicine exhibiting a pH- dependent solubility and a porous. cellulose, elusion of the medicine is controlled by supporting an acid or a base on the porous cellulose. The preparation may be carried out by supporting the medicine and an acid or a base on the porous cellulose or by using a coating film containing the medicine and an acid or a base. The composition for pharmaceutical preparation obtained by supporting an acid or a base on the porous cellulose is useful for controlling elusion of the medicine. The preparation may contain an additive such as a binder. A solid preparation such as powder, granule, tablet or capsule can be used as the dosage form.
Naoyuki Uenishi
Toshio Kashihara