Title:
G2期細胞周期停止の阻害、およびDNA損傷剤に対する細胞感作のための組成物および方法
Document Type and Number:
Japanese Patent JP4610828
Kind Code:
B2
Abstract:
The invention provides compositions and methods for inhibiting Chk1 and/or Chk2 kinases. Also provided are compositions and methods for inhibiting G2 cell arrest checkpoint, particularly in mammalian, e.g., human, cells. The compositions and methods of the invention are also used to treat disorders of cell growth, such as cancer. In particular, the invention provides methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA damaging agents and treatments. Also provided are methods for screening for compounds able to interact with, e.g., inhibit, enzymes involved in the G2 cell cycle arrest checkpoint, such as Chk1 and/or Chk2/Cds1 kinase.
Inventors:
Suganuma Shoji
Takumi Kawabe
Takumi Kawabe
Application Number:
JP2001525330A
Publication Date:
January 12, 2011
Filing Date:
September 21, 2000
Export Citation:
Assignee:
Canvas Co., Ltd.
International Classes:
C12N15/09; A61K31/506; G01N33/50; A61K31/704; A61K33/24; A61K35/76; A61K38/00; A61K38/04; A61K45/00; A61K48/00; A61P35/00; A61P43/00; C07H15/252; C07K7/06; C07K14/16; C07K14/47; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N9/16; C12N9/99; C12N15/11; C12N15/62; C12Q1/48; G01N33/15; G01N33/53; G01N33/566; G01N33/574; G01N33/68
Foreign References:
| WO1994028914A1 | ||||
| WO1998030680A1 |
Other References:
X WANG,JOURNAL OF AMERICAN CHEMICAL SOCIETY,米国,1997年,V119 N27,P6444-6445
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita