Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF WOUNDS, DISORDERS, AND DISEASES OF SKIN
Document Type and Number:
Japanese Patent JP2022023174
Kind Code:
A
Abstract:
To provide compositions and methods for treating wounds, disorders, and diseases of the skin.SOLUTION: The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha- 1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.SELECTED DRAWING: Figure 3
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Inventors:
SUMA KRISHNAN
POOJA AGARWAL
POOJA AGARWAL
Application Number:
JP2021175260A
Publication Date:
February 07, 2022
Filing Date:
October 27, 2021
Export Citation:
Assignee:
KRYSTAL BIOTECH INC
International Classes:
A61K48/00; A61K35/763; A61P17/00
Other References:
MIYAGAWA, YOSHITAKA ET AL.: "Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxic", PNAS, JPN6020046714, 2015, pages 1632 - 1641, ISSN: 0005029198
MARCONI, PEGGY ET AL.: "Replication-defective herpes simplex virus vectors for gene transfer in vivo", PROC. NATL. ACAD. SCI. USA, vol. 93, JPN6020046715, 1996, pages 11319 - 11320, XP002106933, ISSN: 0005029199, DOI: 10.1073/pnas.93.21.11319
STEPHEN A WATT ET AL.: "Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessi", PLOS ONE, vol. 10, no. 9, JPN6022044452, 2015, pages 0137639, ISSN: 0005029200
KEVIN M. MCGOWAN ET AL.: "Keratin 17 null mice exhibit age- and strain-dependent alopecia", GENES & DEV, vol. 16, JPN6022044454, 2002, pages 1412 - 1422, XP093115332, ISSN: 0005029201, DOI: 10.1101/gad.979502
MARCONI, PEGGY ET AL.: "Replication-defective herpes simplex virus vectors for gene transfer in vivo", PROC. NATL. ACAD. SCI. USA, vol. 93, JPN6020046715, 1996, pages 11319 - 11320, XP002106933, ISSN: 0005029199, DOI: 10.1073/pnas.93.21.11319
STEPHEN A WATT ET AL.: "Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessi", PLOS ONE, vol. 10, no. 9, JPN6022044452, 2015, pages 0137639, ISSN: 0005029200
KEVIN M. MCGOWAN ET AL.: "Keratin 17 null mice exhibit age- and strain-dependent alopecia", GENES & DEV, vol. 16, JPN6022044454, 2002, pages 1412 - 1422, XP093115332, ISSN: 0005029201, DOI: 10.1101/gad.979502
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Michiko Uehara
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Michiko Uehara
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