Title:
COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
Document Type and Number:
Japanese Patent JP2015145392
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using the compounds and compositions.SOLUTION: This invention relates to a compound represented by formula (I), where Z is a bond, -C(R1)(R2)- or the like; G is -N(R42)-SO2-R40 or the like ; R3 and R4 are H, alkyl or the like; R11 and R12 are hydrogen, alkyl or the like; R33 is halogen, OR34, alkyl or the like; and n is 0-4.
Inventors:
SCOTT IAN L
VLADIMIR A KUKSA
HONG FENG
KUBOTA MAKOTO
JENNIFER GAGE
VLADIMIR A KUKSA
HONG FENG
KUBOTA MAKOTO
JENNIFER GAGE
Application Number:
JP2015053695A
Publication Date:
August 13, 2015
Filing Date:
March 17, 2015
Export Citation:
Assignee:
ACUCELA INC
International Classes:
C07C211/49; A61K31/136; A61K31/137; A61K31/167; A61K31/17; A61K31/18; A61K31/426; A61P27/02; A61P43/00; C07C215/16; C07C215/42; C07C215/68; C07C215/70; C07C217/08; C07C217/10; C07C217/54; C07C217/66; C07C225/22; C07C233/40; C07C233/43; C07C233/62; C07C275/40; C07C311/08; C07C311/10; C07C311/14; C07C311/21; C07C311/24; C07C335/18; C07D277/28
Domestic Patent References:
| JP2006502118A | 2006-01-19 | |||
| JPH10510248A | 1998-10-06 | |||
| JP2008500284A | 2008-01-10 | |||
| JPH0812579A | 1996-01-16 | |||
| JP5773877B2 | 2015-09-02 | |||
| JP2006505511A | 2006-02-16 | |||
| JP2006501195A | 2006-01-12 | |||
| JP2007536280A | 2007-12-13 | |||
| JP2006508101A | 2006-03-09 | |||
| JP2004535390A | 2004-11-25 | |||
| JP2003518057A | 2003-06-03 | |||
| JPH08176080A | 1996-07-09 | |||
| JP2007531731A | 2007-11-08 | |||
| JP2001519355A | 2001-10-23 | |||
| JPS4825932B1 | 1973-08-02 | |||
| JPH06329535A | 1994-11-29 |
Foreign References:
| US3341584A | 1967-09-12 | |||
| US20030216456A1 | 2003-11-20 | |||
| GB1108577A | 1968-04-03 | |||
| WO2004033419A1 | 2004-04-22 | |||
| US20030100580A1 | 2003-05-29 | |||
| WO2007139923A1 | 2007-12-06 |
Other References:
R.J. ALTENBACH, ET AL: "Synthesis and structure-activity studies on N-(5-(1H-imidazol-4-yl)-5 ,6,7,8-tetrahydro-1-naphthalen", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, JPN6013042518, 2004, pages 3220 - 3235, XP002438696, ISSN: 0003226829, DOI: 10.1021/jm030551a
SIKAZWE, DONALD; BONDAREV, MIKHAIL L.; DUKAT, MALGORZATA; RANGISETTY, JAGADEESH B.; ROTH, BRYAN: "Binding of Sulfonyl-Containing Arylalkylamines at Human 5-HT6 Serotonin Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49(17), JPN6013042520, 2006, pages 5217 - 5225, ISSN: 0003226830
WASHBURN W. N. ET AL: "Arylpropanolamines: Selective .beta.3 agonists arising from strategies to mitigate phase I metabolic", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 17, JPN6013042523, 2007, pages 4290 - 4296, XP022144691, ISSN: 0003226831, DOI: 10.1016/j.bmcl.2007.05.030
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 81, JPN6014054001, 1959, pages 6207 - 6209, ISSN: 0003433246
SIKAZWE, DONALD; BONDAREV, MIKHAIL L.; DUKAT, MALGORZATA; RANGISETTY, JAGADEESH B.; ROTH, BRYAN: "Binding of Sulfonyl-Containing Arylalkylamines at Human 5-HT6 Serotonin Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49(17), JPN6013042520, 2006, pages 5217 - 5225, ISSN: 0003226830
WASHBURN W. N. ET AL: "Arylpropanolamines: Selective .beta.3 agonists arising from strategies to mitigate phase I metabolic", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 17, JPN6013042523, 2007, pages 4290 - 4296, XP022144691, ISSN: 0003226831, DOI: 10.1016/j.bmcl.2007.05.030
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 81, JPN6014054001, 1959, pages 6207 - 6209, ISSN: 0003433246
Attorney, Agent or Firm:
Asamura patent office