Title:
ミクロソーム・トリグリセリド転移プロテインの立体配座制限芳香族抑制剤および方法
Document Type and Number:
Japanese Patent JP4129993
Kind Code:
B2
Abstract:
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0,1 or 2; R is H, alkyl, aryl or halogen; A is (1) a bond; (2) -O-; or (3) (i); B is: (ii) or (iii) or (iv) or (v) (wherein (a = 2, 3 or 4)) or (vi) or (vii) or (viii); and wherein L<2>, L<1>, R<1>, R<2>, R<3>, R<3'>, R<3a>, R<3b>, R<4>, R<4'>, R<5>, X, (ix), (x) and (xi) are as defined herein.
Inventors:
Biller, Scott A
Dickson, John Kay
Lawrence, Earl Michael
Magnin, David Earl
Poss, Michael A.
Roble, Jeffrey A.
Sulsarchic, william a
Salkey, Richard Bee
Tino, Joseph A.
Dickson, John Kay
Lawrence, Earl Michael
Magnin, David Earl
Poss, Michael A.
Roble, Jeffrey A.
Sulsarchic, william a
Salkey, Richard Bee
Tino, Joseph A.
Application Number:
JP52612797A
Publication Date:
August 06, 2008
Filing Date:
January 13, 1997
Export Citation:
Assignee:
Bristol-Myers Squibb Company
International Classes:
C07C233/57; A61K31/00; A61K31/191; A61K31/34; A61K31/341; A61K31/365; A61K31/366; A61K31/38; A61K31/381; A61K31/382; A61K31/39; A61K31/40; A61K31/4025; A61K31/403; A61K31/4035; A61K31/404; A61K31/41; A61K31/415; A61K31/4184; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/428; A61K31/433; A61K31/435; A61K31/44; A61K31/4427; A61K31/443; A61K31/445; A61K31/4468; A61K31/505; A61K31/52; A61K31/535; C07C17/093; C07C33/34; C07C47/453; C07C49/225; C07C49/252; C07C49/563; C07C49/567; C07C49/573; C07C69/00; C07C205/11; C07C205/43; C07C205/55; C07C233/58; C07C233/59; C07C233/60; C07C233/62; C07C233/63; C07C233/78; C07C235/40; C07C235/56; C07C237/22; C07C237/24; C07C255/41; C07C259/08; C07C271/22; C07C291/04; C07C311/19; C07C311/21; C07C311/37; C07C311/42; C07C311/46; C07C317/12; C07C321/22; C07C323/60; C07D207/335; C07D207/38; C07D209/08; C07D209/16; C07D209/34; C07D209/38; C07D209/46; C07D209/48; C07D211/60; C07D211/62; C07D213/40; C07D213/64; C07D213/74; C07D213/75; C07D213/80; C07D213/89; C07D221/16; C07D231/56; C07D233/24; C07D233/54; C07D233/78; C07D233/84; C07D233/88; C07D233/90; C07D235/06; C07D235/08; C07D235/16; C07D235/24; C07D235/26; C07D235/28; C07D235/30; C07D239/38; C07D239/42; C07D239/46; C07D249/12; C07D249/14; C07D249/18; C07D253/06; C07D253/07; C07D263/38; C07D263/46; C07D263/58; C07D271/07; C07D277/20; C07D277/36; C07D277/56; C07D277/74; C07D285/08; C07D285/125; C07D295/108; C07D295/155; C07D295/185; C07D307/14; C07D307/52; C07D311/84; C07D317/30; C07D317/58; C07D319/06; C07D327/06; C07D333/20; C07D335/14; C07D335/20; C07D401/04; C07D401/12; C07D403/04; C07D405/12; C07D407/12; C07D409/12; C07D417/04; C07D417/12; C07D471/04; C07D473/34; C07D487/04; C07F7/18; C07F9/40; C07F9/58; C07F9/59; C07F9/6506; C07F9/6533; C07F9/655; C07D207/32; C07D271/06; C07D285/12
Domestic Patent References:
| JP57004954A | ||||
| JP11500442A |
Foreign References:
| EP0643057A1 | ||||
| GB1147832B | ||||
| AT368130B | ||||
| US4197313 | ||||
| GB773756B |
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura