Title:
THERAPEUTIC DLL4 BINDING PROTEINS
Document Type and Number:
Japanese Patent JP2016185961
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide, for a vasculature ligand for the Notch receptor being Delta 4 or Delta-like 4 (DLL4), development and use of DLL4 binding proteins and methods of inhibition, prevention and/or treatment of cancers, tumors, other angiogenesis-dependent diseases, angiogenesis-independent diseases, and macular degeneration and age-related macular degeneration diseases characterized by aberrant DLL4 expression or activity.SOLUTION: The invention provides antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity.SELECTED DRAWING: None
Inventors:
LI YINGCHUN
JIJIE JAMES GU
SUSAN MORGAN-LAPPE
CHEN MINGJIU
HSIEH CHUNG-MING
JIJIE JAMES GU
SUSAN MORGAN-LAPPE
CHEN MINGJIU
HSIEH CHUNG-MING
Application Number:
JP2016092639A
Publication Date:
October 27, 2016
Filing Date:
May 02, 2016
Export Citation:
Assignee:
ABBVIE INC
International Classes:
C07K14/47; A61K38/00; A61K39/395; A61K49/00; A61K51/00; A61P9/00; A61P35/00; C07K16/18; C07K16/46
Domestic Patent References:
| JP2009539384A | 2009-11-19 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office