Title:
バイオプロテーゼ製造用外来材料のデセルラライズ方法
Document Type and Number:
Japanese Patent JP2004531291
Kind Code:
A
Abstract:
The invention relates to a method for decellularising allogenic and xenogenic foreign material for the subsequent production of bioprostheses, coated with endogenous body cells, whereby the foreign material is firstly treated in a solution of bile acid and then alcohol, each with an intermediate or subsequent rinsing step, in combination with a mechanical action on the tissue and the cells by the force generated from a flowing treatment medium, at least in the final rinsing step. After said treatment the tissue is completely rid of foreign cell material and viruses and represents an excellent starting material for the coating with cells of the bioprosthesis recipient.
Inventors:
Wolfgang Konerz
Pascal domen
Pascal domen
Application Number:
JP2002551018A
Publication Date:
October 14, 2004
Filing Date:
December 05, 2001
Export Citation:
Assignee:
Auto Tissue GmbH
International Classes:
A61L2/18; A61F2/24; A61L2/00; A61L2/02; A61L27/00; A61L27/36; C12N5/08; (IPC1-7): A61L27/00; A61L2/18
Domestic Patent References:
| JPS60500014A | 1985-01-10 | |||
| JPH06218036A | 1994-08-09 |
Foreign References:
| WO1996039814A1 | 1996-12-19 | |||
| WO1999022747A1 | 1999-05-14 | |||
| WO1999032049A1 | 1999-07-01 |
Other References:
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ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＲＤＩＯ−ＴＨＯＲＡＣＩＣ ＳＵＲＧＥＲＹ, vol. 14, no. 3, JPN6008020465, 1998, pages 279 - 284, ISSN: 0001034520
ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＭＥＤＩＣＡＬ ＭＡＴＥＲＩＡＬＳ ＲＥＳＥＡＲＣＨ, vol. 46, no. 4, JPN6008020470, 1999, pages 531 - 538, ISSN: 0001034521
ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＭＥＤＩＣＡＬ ＭＡＴＥＲＩＡＬＳ ＲＥＳＥＡＲＣＨ, vol. 49, no. 1, JPN6008020467, 2000, pages 134 - 140, ISSN: 0001034522
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Attorney, Agent or Firm:
Mitsuo Tanaka
Hiromitsu Takayama
Minato Saito
Hiromitsu Takayama
Minato Saito