Title:
象牙質由来のヘパラン硫酸に特異的なモノクローナル抗体
Document Type and Number:
Japanese Patent JP5123627
Kind Code:
B2
Abstract:
The present invention provides a monoclonal antibody displaying excellent specificity against heparan sulfate saccharide chains for the analysis of heparan sulfate saccharide chains specific to dentin. The invention also provides a method of evaluating reproductive dentin using the monoclonal antibody. The anti-heparan sulfate monoclonal antibody reacts against dentin-derived heparan sulfate and in particular the anti-heparan sulfate monoclonal antibody reacts strongly and specifically with uncalcified predentin regions. In the method of evaluating dentin, the antibody is reacted against an isolated dentin-derived sample and the reaction is used in order to evaluate the development of dentin.
Inventors:
Akiko Hisada
Ryosuke Takahashi
Hiroko Hanzawa
Ryosuke Takahashi
Hiroko Hanzawa
Application Number:
JP2007247798A
Publication Date:
January 23, 2013
Filing Date:
September 25, 2007
Export Citation:
Assignee:
株式会社日立製作所
International Classes:
C07K16/28; C12N5/10; G01N33/53; G01N33/577
Domestic Patent References:
| JP2007078705A |
Other References:
J. Cell Biol.,1992年,vol.119, no.4,pp.961-975
Attorney, Agent or Firm:
Yusuke Hiraki