Title:
【発明の名称】抗―高コレステロール血症、抗―高リポ蛋白血症及び抗―高血糖症剤としての置換されたピリジン類及びビフェニル類
Document Type and Number:
Japanese Patent JP2001512416
Kind Code:
A
Abstract:
Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formulawhereinR1a and R1b independently represent (C1-C6) alkyl; R2 represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the substituents are independently from 1 to 3 of -SR7; R7 represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C1-C6) alkyl, (C1-C6) alkoxy, nitro, cyano, or hydroxyl; R3 represents substituted (C1-C6) alkyl wherein the substituents are 1-2 hydroxyl groups; G represents a substituent selected from the group consisting of halogen, (C1-C6) alkyl, and OR4 wherein R4 is H or (C1-C6) alkyl; and y is 0 or an integer of 1-3. Pharmaceutical compositions containing such compounds and methods of treatment of glucagon-mediated conditions by administering such compounds are also claimed.
Inventors:
Schmitt, Gunter
Angerbauer, Rolf
Brandes, Arndt
Miura-Gleemann, Matias
Bishyov, Hilmer
Schmidt, Delf
Ball File, Shute Juan
Shion, William Earl
Radeuil, Getan H
Kutsuku, The Ames H, The Second
Reese, Timothy G
Wollanine, Donald J. Ray
Crumbs, Lithium H
Herzog, Donald El
Osterhout, Martin H
Angerbauer, Rolf
Brandes, Arndt
Miura-Gleemann, Matias
Bishyov, Hilmer
Schmidt, Delf
Ball File, Shute Juan
Shion, William Earl
Radeuil, Getan H
Kutsuku, The Ames H, The Second
Reese, Timothy G
Wollanine, Donald J. Ray
Crumbs, Lithium H
Herzog, Donald El
Osterhout, Martin H
Application Number:
JP50906898A
Publication Date:
August 21, 2001
Filing Date:
July 29, 1997
Export Citation:
Assignee:
BAYER CORPORATION
Bayer Actien Gezershyaft
Bayer Actien Gezershyaft
International Classes:
A61K31/045; A61K31/055; A61K31/075; A61K31/10; A61K31/425; A61K31/426; A61K31/435; A61K31/44; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4436; A61K31/4439; A61K31/451; A61K31/4545; A61K31/47; A61K31/496; A61K31/5377; A61P3/10; C07C33/46; C07C39/12; C07C39/205; C07C39/367; C07C43/178; C07C323/16; C07C323/20; C07D213/24; C07D213/30; C07D213/32; C07D213/34; C07D213/36; C07D213/38; C07D213/50; C07D213/55; C07C33/24; C07D213/64; C07D213/70; C07D213/74; C07D213/80; C07D215/14; C07D221/04; C07D275/02; C07D277/22; C07D401/06; C07D401/12; C07D403/04; C07D403/06; C07D405/04; C07D405/06; C07D405/12; C07D407/04; C07D409/04; C07D411/12; C07D413/04; C07D413/06; C07D413/12; C07D417/04; C07D417/12; C07D419/04; C07D487/04; C07D521/00; C07F7/18; C07D211/26; (IPC1-7): C07D213/30; A61K31/045; A61K31/055; A61K31/075; A61K31/10; A61K31/425; A61K31/426; A61K31/435; A61K31/4409; A61K31/443; A61K31/4436; A61K31/4439; A61K31/451; A61K31/4545; A61K31/47; A61K31/496; A61K31/5377; A61P3/10; C07C33/46; C07C39/367; C07C43/178; C07C323/16; C07C323/20; C07D213/32; C07D213/34; C07D213/38; C07D213/55; C07D215/14; C07D221/04; C07D275/02; C07D277/22; C07D401/06; C07D405/04; C07D405/06; C07D409/04
Attorney, Agent or Firm:
Heiyoshi Odashima (1 person outside)