Title:
間質性肺疾患の診断および治療方法
Document Type and Number:
Japanese Patent JP2006519588
Kind Code:
A
Abstract:
The present invention provides for a method of treating pulmonary disease in a subject comprising the administration to a subject in need of such treatment a therapeutically effective amount of a formulation comprising a SP-C therapeutic. Preferably, the SP-C therapeutic is an agent selected from the group consisting of an isolated SP-C protein, an isolated nucleic acid molecule encoding a SP-C protein, a SP-C receptor-specific antibody that stimulates the activity of the receptor, or pharmaceutically acceptable composition thereof. The present invention also provides methods of producing a mouse with a targeted disruption in a surfactant protein C (SP-C) gene. The present invention also provides for a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene. The present invention further provides for a cell or cell line from a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene.
Inventors:
Whitset, Jeffrey A.
Grasser, Stephen W
Grasser, Stephen W
Application Number:
JP2004562253A
Publication Date:
August 31, 2006
Filing Date:
December 09, 2003
Export Citation:
Assignee:
Children's Hospital Medical Center
International Classes:
C12N15/09; A01K67/027; A61K31/352; A61K31/56; A61K31/7088; A61K31/727; A61K35/76; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61K47/30; A61K47/48; A61K48/00; A61P11/00; A61P11/06; A61P11/08; A61P27/16; A61P29/00; A61P33/00; A61P37/08; C07K14/785; C12N5/10; C12N15/85
Attorney, Agent or Firm:
Michiteru Soga
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku